X-Men 2 may refer to:
- X2 (film), a 2003 superhero film sequel based on the fictional characters the X-Men
- X2: Wolverine's Revenge, a 2003 video game focusing on the character Wolverine
- X-Men 2: Clone Wars, a 1995 video game by Sega for the Mega Drive/Genesis
- X-Men II: The Fall of the Mutants, a role-playing DOS game for the PC
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