thumb|right|Plaque commemorating the gift to the city
Wythenshawe Hall is a 16th-century timber-framed historic house and former manor house in Wythenshawe, Manchester, England, south of the city centre in Wythenshawe Park. Built for Robert Tatton, it was home to the Tatton family for almost 400 years. Its basic plan is a central hall with two projecting wings.
In the winter of 1643–44, the house was besieged by Parliamentarian forces during the English Civil War. Despite the stout defence put up by Tatton and his fellow Royalists, the defenders were overwhelmed by the Roundheads' superior weaponry.
Rebuilding work was carried out at the end of the 18th century, and various additions made in the 19th century, including a walled garden, an ice house, glass houses and a tenant's hall.