Wyalusing may refer to:
;United States
- Wyalusing, Pennsylvania, a borough in Bradford County
- Wyalusing Township, Pennsylvania, in the above borough
- Wyalusing, Wisconsin, a town in Grant County
- Wyalusing (community), Wisconsin, an unincorporated community in the above town
USS Wyalusing (1863), a United States Navy gunboat of the American Civil War, named for Wyalusing, Pennsylvania