Wolfen may refer to:
Places
- Wolfen, Germany, town in Saxony-Anhalt
Fiction
- The Wolfen, 1978 horror novel by Whitley Strieber
- Wolfen (film), 1981 horror film
Gaming
- An enemy in Kya: Dark Lineage
- Wolfen, the ships used by the Star Wolf team in the Star Fox series
- A species of wolf-like humanoids in Rackham's Cadwallon role-playing game and Confrontation miniatures game
Other uses
- ORWO, (Original Wolfen), a brand of photographic films