Significantly, he later described how, as a child, he'd seen an apparition of a green reindeer in the woods, which he identified as a totem animal, as well as a vision of ghostly gray figures at play in his bedroom.

As a boy, Burroughs lived on Pershing Avenue (now Pershing Place) in St. Louis's Central West End. He attended John Burroughs School in St. Louis, where his first published essay — "Personal Magnetism", which revolved around telepathic mind-control — was printed in the John Burroughs Review in 1929. He then attended the Los Alamos Ranch School in New Mexico, which was stressful for him. The school was a boarding school for the wealthy, "where the spindly sons of the rich could be transformed into manly specimens". He kept his sexual orientation concealed from his family well into adulthood. A common story says that he was expelled from Los Alamos after taking chloral hydrate in Santa Fe with a fellow student. Yet, according to his own account, he left voluntarily: "During the Easter vacation of my second year I persuaded my family to let me stay in St. Louis."

Europe and first marriage

After Burroughs graduated from Harvard, his formal education ended, except for brief flirtations with graduate study of anthropology at Columbia and medicine in Vienna, Austria. He traveled to Europe and became involved in Austrian and Hungarian Weimar-era gay culture; he picked up young men in steam baths in Vienna and moved in a circle of exiles, homosexuals, and runaways. There, he met Ilse Klapper, born Herzfeld (1900–1982), a German Jewish woman fleeing her country's Nazi government. The two were never romantically involved, but Burroughs married her, in Croatia, against the wishes of his parents, to allow her to gain a visa to the United States. She made her way to New York City, and eventually divorced Burroughs, although they remained friends for many years. This event made its way into his early fiction as the novella The Finger.

Beginning of the Beats

Burroughs enlisted in the U.S. Army early in 1942, shortly after the bombing of Pearl Harbor brought the United States into World War II. But when he was classified as a not an officer, he became dejected. His mother recognized her son's depression and got Burroughs a civilian disability discharge – a release from duty based on the premise that he should have not been allowed to enlist due to previous mental instability. After being evaluated by a family friend, who was also a neurologist at a psychiatric treatment center, Burroughs waited five months in limbo at Jefferson Barracks outside St. Louis before being discharged. During that time he met a Chicago soldier also awaiting release, and once Burroughs was free, he moved to Chicago and held a variety of jobs, including one as an exterminator. When two of his friends from St. Louis – University of Chicago student Lucien Carr and his sexual assaulter, David Kammerer – left for New York City, Burroughs followed.

Addiction and Joan Vollmer

In 1945, Burroughs began living with Joan Vollmer Adams in an apartment they shared with Jack Kerouac and Edie Parker, Kerouac's first wife. Vollmer Adams was married to a G.I. with whom she had a young daughter, Julie Adams.

Burroughs and Kerouac got into trouble with the law for failing to report a murder involving Lucien Carr, who had killed David Kammerer in a confrontation allegedly over Kammerer's unwanted advances. This incident inspired Burroughs and Kerouac to collaborate on a novel titled And the Hippos Were Boiled in Their Tanks, completed in 1945. The two fledgling authors were unable to get it published during their lifetimes, but the manuscript was eventually published in November 2008 by Grove Press and Penguin Books.

During this time, Burroughs began using morphine and became addicted. He eventually sold heroin in Greenwich Village to support his habit. Vollmer also became an addict, but to Benzedrine, an amphetamine sold over the counter at that time. Because of her addiction and social circle, her husband immediately divorced her after returning from the war. With urging from Allen Ginsberg, and also perhaps Kerouac, Burroughs became intellectually and emotionally linked with Vollmer and by summer 1945, had moved in with Vollmer and her daughter. In spring 1946, Burroughs was arrested for forging a narcotics prescription. Vollmer asked her psychiatrist, Lewis Wolberg, to sign a surety bond for Burroughs's release. As part of his release, Burroughs returned to St. Louis under his parents' care, after which he left for Mexico to get a divorce from Ilse Klapper. Meanwhile, Vollmer's addiction led to a temporary psychosis that resulted in her admission to Bellevue Hospital, which endangered the custody of her child. Upon hearing this, Burroughs immediately returned to New York City to gain her release, asking her to marry him. Their marriage was never formalized, but she lived as his common-law wife. In 2025, it emerged that Burroughs married a Mexican woman named María Lucrecia Barquera on November 23, 1949, probably for immigration reasons. He kept this a secret for the rest of his life.

They returned to St. Louis to visit Burroughs's parents and then moved with her daughter to Texas. Vollmer soon became pregnant with Burroughs's child. Their son, William S. Burroughs Jr., was born in 1947. The family moved briefly to New Orleans in 1948.

Mexico and South America (1950–1952)

In New Orleans, police stopped Burroughs's car one evening. They found an unregistered handgun belonging to him as well as a letter from Ginsberg that contained details about the sale of marijuana. The police then searched Burroughs's home, where they discovered his stash of drugs and half a dozen or more firearms. Burroughs fled to Mexico to escape possible detention in Louisiana's Angola State Prison. Vollmer and their children followed him. Burroughs planned to stay in Mexico for at least five years, the length of his charge's statute of limitations. Burroughs also attended classes at the Mexico City College in 1950, studying Spanish, as well as Mesoamerican manuscripts (codices) and the Mayan language with R. H. Barlow.

Killing of Vollmer

Their life in Mexico was by all accounts an unhappy one. Without heroin and suffering from Benzedrine abuse, Burroughs began to pursue other men as his libido returned, while Vollmer, feeling abandoned, started to drink heavily and mock Burroughs openly. a drunk Burroughs allegedly took his handgun from his travel bag and told his wife, "It's time for our William Tell act." There is no indication that they had performed such an action previously.

Soon after the incident, Burroughs changed his account, claiming that he had dropped his gun and it had accidentally fired. Burroughs spent 13 days in jail before his brother came to Mexico City and bribed Mexican lawyers and officials to release Burroughs on bail while he awaited trial for the killing, which was ruled culpable homicide.

Vollmer's daughter, Julie Adams, went to live with her grandmother, and William S. Burroughs Jr. went to St. Louis to live with his grandparents. Burroughs reported every Monday morning to the jail in Mexico City while his prominent Mexican attorney worked to resolve the case. According to James Grauerholz, two witnesses had agreed to testify that the gun had fired accidentally while he was checking to see if it was loaded, with ballistics experts bribed to support this story.

The Yage Letters

After leaving Mexico, Burroughs drifted through South America for several months, seeking out a drug called yagé, which promised to give the user telepathic abilities. A book composed of letters between Burroughs and Ginsberg, The Yage Letters, was published in 1963 by City Lights Books. In 2006, a re-edited version, The Yage Letters Redux, showed that the letters were largely fictionalised from Burroughs's notes.

Beginning of literary career

Burroughs described Vollmer's death as a pivotal event in his life, and one that provoked his writing by exposing him to the risk of possession by a malevolent entity he called "the Ugly Spirit":

<blockquote>I am forced to the appalling conclusion that I would never have become a writer but for Joan's death, and to a realization of the extent to which this event has motivated and formulated my writing. I live with the constant threat of possession, and a constant need to escape from possession, from Control. So the death of Joan brought me in contact with the invader, the Ugly Spirit, and maneuvered me into a life long struggle, in which I have had no choice except to write my way out.</blockquote>

As Burroughs makes clear, he meant this reference to "possession" to be taken absolutely literally, stating: "My concept of possession is closer to the medieval model than to modern psychological explanations ... I mean a definite possessing entity." – to disrupt language via methods such as the cut-up technique, and thus protect himself from possession.