William Bryan is the name of the following people:
- William Alanson Bryan (1875–1942), American zoologist, ornithologist, naturalist and museum director
- William C. Bryan (1852–1933), United States Army soldier and Medal of Honor recipient
- William E. Bryan Jr. (1921–2008), United States Air Force major general and flying ace
- William James Bryan (1876–1908), U.S. Senator from Florida
- William Jennings Bryan (1860–1925), orator and three-time Democratic nominee for U.S. President
- William Joel Bryan (1815–1903), Texas soldier and land owner, namesake of Bryan, Texas
- William Joseph Bryan (1926–1977), American hypnotist
- William Lowe Bryan (1860–1955), 10th president of Indiana University
- William Bryan (cricketer) (1856–1933), English cricketer
- William Bryan (North Carolina politician) (1725–1781), American militia general and politician
- Billy Bryan (born 1955), American football player
- Billy Bryan (baseball) (1938–2026), American former Major League Baseball catcher
- William Bryan (died 1993), British murder victim
- William "Roddie" Bryan (born 1969), American convicted for the murder of Ahmaud Arbery
See also
- William Brien (disambiguation)
- William O'Bryan (1778–1868), founder of the Bible Christians
- William Bryant (disambiguation)