William Bruce may refer to:
- William Bruce (diplomat) (died 1610), Scottish author and diplomat in Poland
- Sir William Bruce (architect) (c. 1630–1710), Scottish architect
- William Bruce, 8th Earl of Kincardine (died 1740), Scottish nobleman
- William Bruce (cricketer) (1864–1925), Australian cricketer
- William Bruce (Canadian politician) (died 1838), physician and politician in Upper Canada
- William Bruce (VC) (1890–1914), posthumous recipient of the Victoria Cross
- William Cabell Bruce (1860–1946), author and United States Senator
- Major William Bruce-Gardyne of Clan Gardyne, Laird of Middleton, Angus, Scotland
- William Speirs Bruce (1867–1921), Scottish explorer
- William George Bruce (1856–1949), Milwaukee publisher, historian, and civic leader
- William Bruce (minister, born 1757) (1757–1841), Irish Presbyterian and educator
- William Bruce (minister, born 1790) (1790–1868), Irish Presbyterian and professor
- William Blair Bruce (1859–1906), Canadian painter
- William Napier Bruce (1858–1936), British educationalist and lawyer
- William J. Bruce III (born 1980), American author and publicist
See also
- Bill Bruce (disambiguation)