Weigel is a German surname. Notable people with this name include:
- Alicia Roth Weigel, American intersex activist and writer
- Beverly Weigel (born 1940), New Zealand Olympic athlete
- Christian Ehrenfried Weigel (1748–1831), German scientist
- Christoph Weigel the Elder (1654–1725), German engraver, art dealer and publisher
- David Weigel (born 1981), American journalist and political commentator
- Detlef Weigel (born 1961), German American scientist
- (1927–1995), née Hofer, Austrian actress, married to Hans Weigel from 1951–1964
- Erhard Weigel (1625–1699), German scientist
- George Weigel (born 1951), American writer and religious commentator
- Hans Weigel (1908–1991), Austrian writer
- Helene Weigel (1900–1971), Austrian actress
- Herman Weigel (born 1950), German film producer and screenwriter
- Jannine Weigel (born 2000), Thai singer-songwriter and actress
- Jaroslav Weigel (1931–2019), Czech actor, writer, playwright, comics writer and painter
- Johanna Weigel "Madame Weigel" (1847–1940), designer and publisher of dressmaking patterns in
- (born 1992), Chilean-French lawyer and actress
- Patrick Weigel (born 1994), American baseball player
- Ronald Weigel (born 1959), German athlete
- Teri Weigel (born 1961/61), American porn actress
- Valentin Weigel (1533–1588), German theologian, philosopher and mystical writer
- William Weigel (1863–1936), US Army general commanding 88th Division in World War I
See also
- Grote & Weigel, American meat company
- Weigel Motors, British maker of automobiles (1907–10)
- Weigel Broadcasting, an American broadcasting company
- Weigl, surname
- Weigle, surname