As of the census of 2000, there were 1,165 people, 494 households, and 363 families residing in the town. The population density was . There were 1,242 housing units at an average density of . The racial makeup of the town was 98.03% White, 0.17% Native American, 1.12% Asian, 0.09% from other races, and 0.60% from two or more races. 0.17% of the population were Hispanic or Latino of any race.
There were 494 households, out of which 23.1% had children under the age of 18 living with them, 65.6% were married couples living together, 5.1% had a female householder with no husband present, and 26.5% were non-families. 22.7% of all households were made up of individuals, and 10.9% had someone living alone who was 65 years of age or older. The average household size was 2.36 and the average family size was 2.75.
In the town, the population was spread out, with 19.9% under the age of 18, 6.4% from 18 to 24, 20.9% from 25 to 44, 32.2% from 45 to 64, and 20.5% who were 65 years of age or older. The median age was 47 years. For every 100 females, there were 95.5 males. For every 100 females age 18 and over, there were 95.6 males.
The median income for a household in the town was $38,056, and the median income for a family was $42,292. Males had a median income of $32,841 versus $23,462 for females. The per capita income for the town was $21,563. 8.1% of the population and 5.2% of families were below the poverty line. Out of the total population, 14.6% of those under the age of 18 and 9.0% of those 65 and older were living below the poverty line.
Communities and locations in the Town of Wayne
- Grove Springs – A hamlet on the shore of Keuka Lake, south of Keuka on NY-54.
- Keuka Village – A hamlet on the shore of Keuka Lake at the junction of NY-54 and NY-230.
- North Urbana – A hamlet on the west town line.
- Sylvan Beach – A hamlet southwest of Wayne hamlet on County Road 97, on the west side of Waneta Lake.
- Wayne – The hamlet of Wayne is on the east town line so that it is partly in Schuyler County. NY-230 passes through the Hamlet.
- Wayne Four Corners – A location in the south part of the town, east of North Urbana.