Wachapreague may refer to:
;People
- The Wachapreague people, an Algonquian people that lived in coastal Virginia centuries ago.
;Places
- Wachapreague, Virginia, a town in Accomack County, Virginia
- Wachapreague Channel, an inlet on the eastern shore of Virginia
;Ships
- USS Wachapreague (AVP-56), a United States Navy seaplane tender laid down in 1943 but converted during construction into the motor torpedo tender USS Wachapreague (AGP-8)
- USS Wachapreague (AGP-8), a United States Navy motor torpedo boat tender in commission from 1944 to 1946