WGN may refer to:
- "World's Greatest Newspaper", former slogan of the Chicago Tribune and the namesake for the WGN broadcasting outlets in Chicago, Illinois.
- WGN (AM), a radio station (720 AM) licensed to Chicago, Illinois, United States
- WGN-TV, a television station (channel 9.1 virtual/19 digital) licensed to Chicago, Illinois, United States
- WGN America, the former name of NewsNation, a cable television network based in Chicago, Illinois, United States
- WFMT, a radio station (98.7 FM) licensed to Chicago, Illinois, United States, which operates on the frequency formerly belonging to the Tribune-owned FM station that used the call sign WGNB from 1945 until 1953
- Shaoyang Wugang Airport, IATA code WGN
- White Gaussian noise
- Additive white Gaussian noise
- The ICAO airline designator for Western Global Airlines
- WGN, Journal of the International Meteor Organization
- WorldGaming Network
- Wigan North Western railway station, located on the West Coast Main Line (station code WGN)