WAFF may refer to:
- Tylwyth Waff, a character in the Dune universe
- WAFF (TV), a television station (channel 15, virtual 48) licensed to Huntsville, Alabama, United States
- Royal West African Frontier Force, a former British Army regiment
- West Asian Football Federation, an association for football in West Asia
- Waveform Audio File Format, a file format for storing an audio bitstream.
- Web Archive (file format), a file format available on Apple devices for saving complete web pages with linked files.