The University of Pennsylvania Health System (UPHS) is a major multi-hospital health system headquartered in Philadelphia, Pennsylvania. UPHS and the Perelman School of Medicine at the University of Pennsylvania together comprise Penn Medicine, a clinical and research entity of the University of Pennsylvania. UPHS hospitals include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Pennsylvania Hospital, Chester County Hospital, Lancaster General Hospital, Princeton Medical Center, and Doylestown Hospital.
The UPHS is home to the first hospital in the United States, Pennsylvania Hospital.
History
The Chester County Hospital and Health System joined UPHS in 2013. Two years later, Lancaster General Health (LG Health) joined the UPHS family. Princeton Health officially merged into UPHS in January 2018. UPHS added Doylestown Hospital as its seventh hospital in 2025. Phoenixville Hospital was sold again by CHS to Tower Health in 2017.
In 2020, University of Pennsylvania-Penn Presbyterian was ranked as the 15th best hospital in the United States by the U.S. News & World Report.
Major facilities
{| class="wikitable sortable"
|-
! Facility
! Location
! Type of facility
! Year opened
! Year joined UPHS
! Notes
|-
| Hospital of the University of Pennsylvania
| University City, Philadelphia, Pennsylvania
| Teaching
| 1874
| 1993
| First university-owned teaching hospital in the United States
| 2013
| 2015
|-
| Perelman Center for Advanced Medicine
| University City, Philadelphia
| Specialist
| 2008
| 2008
| Houses the Abramson Cancer Center and Roberts Proton Therapy Center
|-
| Penn Medicine University City
| University City, Philadelphia
| Specialist
|
|
| Home to the Penn Musculoskeletal Center
|-
| Penn Medicine Rittenhouse
| Southwest Center City, Philadelphia
| Rehabilitation
| 1916
| 1997
| Houses the Penn Medicine Institute for Rehabilitation Medicine (operated by Good Shepherd Penn Partners) and the Specialty Hospital at Rittenhouse
|-
| Penn Medicine Radnor
| Radnor Township, PA
| Outpatient
|
|
| Comprehensive primary and specialized outpatient care.
|-
| Penn Medicine Cherry Hill
| Cherry Hill, NJ
| Outpatient
|-
| Women & Babies Hospital
| Lancaster, PA
| Specialist
| 2000
|}