U of C refers to a number of institutions of higher education around the world, including the following:
;Australia:
- University of Canberra (Australian Capital Territory)
;Canada
- University of Calgary (Alberta)
;New Zealand
- University of Canterbury (Christchurch)
;Portugal
- University of Coimbra
;Spain
- University of Cantabria
;United Kingdom
- University of Cambridge
;United States
- University of California system
- University of Charleston (West Virginia)
- University of Chicago (Illinois)
- University of Cincinnati (Ohio)
- University of Colorado system, officially uses the acronym CU
- University of Connecticut