USS Seawolf may refer to:
- , renamed before launching, was the lead ship of the H-class of submarine. Commissioned in 1913, she ran aground and sank in 1920
- was a . Commissioned in 1939, she was successful during World War II until she was lost to friendly fire in 1944
- was the second nuclear submarine. She was commissioned in 1957 and stricken in 1987
- is the lead ship of her class. She was commissioned in 1997 and is currently in active service
See also
- , including the SSN-21
- Seawolf (disambiguation)