USS S-46 (SS-157) was a third-group (S-42) S-class submarine of the United States Navy.
Construction and commissioning
S-46′s keel was laid down on 23 February 1921 by the Bethlehem Shipbuilding Corporation's Fore River Shipyard in Quincy, Massachusetts. She was launched on 11 September 1923, sponsored by Miss Grace Roosevelt, and commissioned on 5 June 1925.