USS S-45 (SS-156) was a third-group (S-42) S-class submarine of the United States Navy.
Construction and commissioning
S-45′s keel was laid down on 29 December 1920 by the Bethlehem Shipbuilding Corporation's Fore River Shipyard in Quincy, Massachusetts. She was launched on 26 June 1923, sponsored by Mrs. Charles Hibbard, and delivered and commissioned on 31 March 1925.