USS Potomac or USNS Potomac may refer to one of these United States Navy ships:
- , a frigate in commission from 1831 to 1877
- , a whaler purchased in 1861 and sunk as part of the "Stone Fleet" in 1862
- , a tug in commission from 1898 to 1922
- , a presidential yacht in service from 1936 to 1945
- , an oiler in service from 1957 until destroyed in a fire in 1961
- , an oiler in service from 1976 to 1983
- USS Potomac (SSN-814), an attack submarine announced in 2025