USS Plymouth may refer to the following ships operated by the United States Navy:
- , a sloop-of-war, was part of Commodore Matthew Perry's Black Fleet
- , a wooden-hulled, screw sloop-of-war, was commissioned as Kenosha and served just after the American Civil War
- , a screw steamer, transported materiel<!--this is correct term for war supplies & "war" is not needed as redundant--> to France during World War I
- , a patrol gunboat, was lost during World War II.