USS Pennsylvania may refer to:
- was a 130-gun ship of the line launched in 1837 and burned to prevent capture in 1861
- A Java-class screw frigate, laid down as Keywaden in 1863 but never launched, was renamed Pennsylvania while she lay in the ways before being broken up in 1884
- was the lead ship of the launched in 1903; renamed Pittsburgh in 1912; scrapped in 1931
- was the lead ship of the launched in 1915 and sunk in 1948, after atomic bomb testing in 1946
- is an launched in 1988 and currently in service