USS Mississippi, named either for the state of Mississippi or the Mississippi River, may refer to:
- , a sidewheel frigate that saw action in the Mexican–American War and was lost during the American Civil War
- , the lead ship of the of battleships; she saw action before World War I and was eventually sold to Greece
- , a that saw action during World War II
- , a nuclear-powered guided missile cruiser
- , a commissioned in 2012
See also
- several towboats of the United States Army Corps of Engineers
- a projected ironclad of the Confederate States Navy
- HMS Wivern (1863) a projected Confederate ironclad turret ram to be named CSS Mississippi; sold to the Royal Navy
- SS Mississippi several steamships in use circa 1862–1931