Four vessels of the United States Navy have been named USS Louisville, after the city of Louisville, Kentucky:
- , was an ironclad steamboat used during the American Civil War
- , was the steamship St. Louis renamed and used in 1918 as a troop transport
- , was a heavy cruiser commissioned in 1931 and active in World War II
- , is a nuclear attack submarine commissioned in 1986 and decommissioned in March 2021
See also
- Louisville (disambiguation)