USS Keokuk may refer to the following ships operated by the United States Navy:
- , was an ironclad warship launched 6 December 1862 and was sunk by Confederate forces on 8 April 1863
- , a mine and net layer acquired by the US Navy 28 July 1941 and sold 7 March 1947
- , is a large harbor tugboat launched 21 May 1964 and currently in active service