Four vessels of the United States Navy have been named USS Charlotte, after the city of Charlotte, North Carolina.
- was a Confederate schooner captured by Federal forces in 1862 and used until 1867.
- was the armored cruiser North Carolina renamed in 1920, a year before decommissioning.
- was a patrol frigate used by the United States Coast Guard during World War II.
- is a nuclear-attack submarine commissioned in 1994.