USS Adirondack may refer to the following ships of the United States Navy:
- , was a gunboat during the American Civil War that sank off the Bahamas
- , was an iron-hulled screw tugboat originally known as Underwriter.
- , was commissioned into the Navy in 1917 and used as a floating barracks until 1919.
- , was an amphibious force flagship in service from 1945 to 1955.