U.S. Route 10 or U.S. Highway 10 (US 10) is an east–west United States Numbered Highway located in the Midwest and Great Lakes regions of the U.S. Despite the "0" as the last digit in the number, US 10 is no longer a cross-country highway, and it never was a full coast-to-coast route. US 10 was one of the original long-haul highways, running from Detroit, Michigan, to Seattle, Washington, but then lost much of its length when new Interstate Highways were built on top of its right-of-way.
US 10 used to be broken into two segments by Lake Michigan. In 2015, the ferry between Ludington, Michigan, and Manitowoc, Wisconsin, was officially designated as part of the highway. The ferry operates only between May and October.
The eastern terminus of US 10 is near Bay City, Michigan, at its interchange with Interstate 75 (I-75) (near US 10's milepost 139 and I-75's milepost 162). The western terminus of US 10 is in the city of West Fargo, North Dakota, at its interchange with I-94.