Tuscumbia is a village in and the county seat of Miller County, Missouri, United States, that is on the Osage River. The population was 188 at the 2020 census. The community's name most likely is a transfer from Tuscumbia, Alabama. A post office called Tuscumbia has been in operation since 1837.

Geography

Tuscumbia is located in central Miller County on the north bank of the Osage River, near the junction of Missouri routes 17 and 52. Route 17 leads northeast to Eugene and southeast to Iberia, while Route 52 leads northwest to Eldon and east to St. Elizabeth.

According to the U.S. Census Bureau, Tuscumbia has a total area of , all land.

2010 census

As of the census of 2010, there were 203 people, 55 households, and 38 families living in the village. The population density was . There were 70 housing units at an average density of . The racial makeup of the village was 93.6% White, 3.9% African American, 2.0% Native American, and 0.5% from other races. Hispanic or Latino of any race were 5.9% of the population.

There were 55 households, of which 34.5% had children under the age of 18 living with them, 47.3% were married couples living together, 12.7% had a female householder with no husband present, 9.1% had a male householder with no wife present, and 30.9% were non-families. 25.5% of all households were made up of individuals, and 9.1% had someone living alone who was 65 years of age or older. The average household size was 2.56 and the average family size was 2.97.

The median age in the village was 36.7 years. 18.2% of residents were under the age of 18; 11.3% were between the ages of 18 and 24; 36.1% were from 25 to 44; 28.1% were from 45 to 64; and 6.4% were 65 years of age or older. The gender makeup of the village was 65.0% male and 35.0% female.

2000 census

As of the census