Tsk or TSK may refer to:
- "tsk!", a dental click
- Tsk Tsk Tsk, an Australian music, art and performance group
- Thaanaa Serndha Koottam, a 2018 Indian Tamil-language crime comedy film by Vignesh Shivan
- "TSK", a song by Nas from Magic 3, 2023
- Galoter process, shale oil extraction technology
- San-in Chūō Television Broadcasting, a Japanese TV station
- Takagi-Sugeno-Kang, a system of Fuzzy logic
- Terrace step kink, a model to describe the thermodynamics of crystal surface formation
- The Sleuth Kit, computer forensics tools
- Tiger Schulmann's Karate
- Tomsk Avia (ICAO: TSK), a Russian airline
- Transmission security keys
- Tseku language (ISO 639:tsk), a language of Tibet
- Turkish Armed Forces (Turkish: Türk Silahlı Kuvvetleri)