Trafficante may refer to:
- Trafficante crime family, mafia crime family in the state of Florida.
- Santo Trafficante Sr. (1886–1954) Sicilian-born mobster, and father of the powerful mobster Santo Trafficante Jr.
- Santo Trafficante Jr. (1914–1987) Powerful Tampa, Florida-born mobster, son of mobster Santo Trafficante Sr.
See also
- James Traficant (19412014), U.S. Representative from Ohio