Topcliffe may refer to:
Places
- Topcliffe, North Yorkshire, a village and civil parish in England
- Topcliffe Castle, an abandoned castle
- Topcliffe railway station (closed)
- RAF Topcliffe, a Royal Air Force station
- Topcliffe, West Yorkshire, a United Kingdom location in Morley, Leeds
People
- John Topcliffe (died 1513), English-born judge
- Richard Topcliffe (1531–1604), English priest hunter