Titu Cusi (Spanish: Diego de Castro Titu Kusi Yupanqui; ; Quechua: Titu Kusi Yupanki ) (15291571) was an Inca ruler of Vilcabamba and the penultimate leader of the Neo-Inca State. He was a son of Manco Inca Yupanqui. He was crowned in 1563, after the death of his half brother, Sayri Túpac. He ruled until his death in 1571, probably of pneumonia.
His 1570 work Relación de la conquista del Peru is a rare account of the Spanish conquest of the Inca Empire from the vantage point of an Inca elite.
Rule
During his rule at Vilcabamba, the provisional governor-general Lope Garcia de Castro wanted to negotiate with him. The negotiations were about Cusi leaving the Vilcabamba and accepting a Crown pension. After negotiations escalated, around 1568, Titu Cusi was baptised into the Catholic Church, as Diego de Castro.