Tiglath-Pileser may refer to:
- Tiglath-Pileser I, king of Assyria from 1115 to 1077 BC
- Tiglath-Pileser II, king of Assyria from 967 to 935 BC
- Tiglath-Pileser III, king of Assyria from 745 to 727 BC
- Tiglath-Pileser, the cat in Agatha Christie's A Murder Is Announced