Thomas Preston may refer to:

Politicians

  • Thomas Preston (MP for Derby), see Derby
  • Thomas Preston (died 1604), MP for Knaresborough
  • Thomas Preston of Gretton, MP for Northampton
  • Thomas Preston (MP for Newcastle-under-Lyme), in 1437 MP for Newcastle-under-Lyme
  • Thomas Preston, in 1452 MP for Wallingford
  • Thomas Preston (of Holker, elder) (1600–1679), English MP for Lancashire
  • Thomas Preston (of Holker, younger) (1647–1697), English MP for Lancaster
  • Thomas Hiram Preston (1855–1925), Ontario journalist and political figure
  • Thomas Hildebrand Preston (1886–1976), British diplomat

Religion

  • Thomas Preston (monk) (1563–1640), English Benedictine monk
  • Thomas Scott Preston (1824–1891), Roman Catholic Vicar General of New York

Others

  • Thomas Preston (composer) (died c. 1563), English composer
  • Thomas Preston (footballer) (1893–1971), Scottish footballer (Airdrieonians)
  • Thomas Preston (writer) (1537–1598), master of Trinity Hall, Cambridge and possible author of King Cambyses
  • Thomas Preston, 1st Viscount Tara (1585–1655), who fought on the side of Confederation in the Irish Confederate Wars (1642–1649)
  • Thomas Preston (British Army officer), involved in the Boston Massacre in 1770
  • Thomas Austin Preston, Jr. (1928–2012), poker player also known as Amarillo Slim
  • Thomas Preston (scientist) (1860–1900), Irish scientist
  • Thomas J. Preston Jr. (1862–1955), professor of archeology at Princeton University
  • Tommy Preston (1932–2015), Scottish footballer (Hibernian)
  • Tom Preston-Werner (born 1979), American entrepreneur (GitHub)