Thomas Robert Cech (born 8 December 1947) is an American chemist who shared the 1989 Nobel Prize in Chemistry with Sidney Altman for their discovery of the catalytic properties of RNA.

Cech discovered that RNA could itself cut strands of RNA, suggesting that life might have started as RNA. He found that RNA can not only transmit instructions, but can act as a catalyst to speed up the necessary reactions.

He has also studied telomeres, and his lab discovered an enzyme, TERT (telomerase reverse transcriptase), which is part of the process of restoring telomeres after they are shortened during cell division.

As president of Howard Hughes Medical Institute (2000–2008) he promoted science education, and he teaches an undergraduate chemistry course at the University of Colorado.

Early life and career

Cech was born to parents of Czech origin (his grandfather was Czech, his other grandparents were first-generation Americans) in Chicago. He grew up in Iowa City, Iowa. In junior high school, he knocked on the doors of geology professors at the University of Iowa, and asked them to discuss crystal structures, meteorites and fossils.

A National Merit Scholar, Cech entered Grinnell College in 1966. There he studied Homer's Odyssey, Dante's Inferno, constitutional history and chemistry. He married his organic chemistry lab partner, Carol Lynn Martinson, and graduated with a B.A. in 1970. In 1978, he obtained his first faculty position at the University of Colorado where he lectured undergraduate students in chemistry and biochemistry, and where he remains on the faculty, currently as distinguished professor in the department of biochemistry. In 2000, Cech succeeded Purnell Choppin as president of the Howard Hughes Medical Institute in Maryland. He also continued to head his biochemistry laboratory at the University of Colorado, Boulder. On April 1, 2008, Cech announced that he would step down as the president of HHMI, to return to teaching and research, in spring 2009. Returning to Boulder, Cech became the first executive director of the BioFrontiers Institute, a position he held until 2020. He also taught general chemistry to freshmen.

Cech is the author of The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets, published in June 2024.

Research

Cech's main research area is that of the process of transcription in the nucleus of cells. He studies how the genetic code of DNA is transcribed into RNA. In the 1970s, Cech had been studying the splicing of RNA in the unicellular organism Tetrahymena thermophila when he discovered that an unprocessed RNA molecule could splice itself. In 1982, Cech became the first to show that RNA molecules are not restricted to being passive carriers of genetic information – they can have catalytic functions and can participate in cellular reactions. and the National Medal of Science (1995). In 1987, Cech was elected to the United States National Academy of Sciences and in 1988 he was elected to the American Academy of Arts and Sciences. Cech was elected to the American Philosophical Society in 2001. In 2003, Cech gave the University of Colorado's George Gamow Memorial Lecture. In 2007, he received the Othmer Gold Medal for outstanding contributions to progress in chemistry and science.

See also

  • History of RNA biology
  • List of RNA biologists

Note

References

Further reading

  • David Oshinsky, "Vaccines at Warp Speed" (review of Thomas R. Cech, The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets, Norton, 2024, 292 pp.), The New York Review of Books, vol. LXXII, no. 5 (27 March 2025), pp. 48–50. In order to create COVID-19 vaccines "[t]here was no need, as with earlier vaccines, to grow, attenuate, and purify large amounts of virus – in this case SARS-CoV-2 – ... because the vaccine no longer contains it. Instead, synthetic mRNA instructs the cells to create a harmless fragment of SARS-CoV-2 that will trigger the immune system to recognize and destroy the virus... [T]he body becomes the factory." (p. 49.) The success of the COVID-19 vaccines "recast the importance of RNA.... [I]t is almost a given, as [the book's author] Cech makes clear, that RNA will power the next generation of pharmaceuticals, which will move beyond infectious diseases to those caused by a 'missing or mutated protein,' such as muscular dystrophy, and numerous cancers caused by 'normal cellular processes gone awry.'... [The question arises, however:] Will this growing focus on 'disease-driven research' overshadow the more traditional 'curiosity-driven' research so vital to scientific advancement?" (p. 50.)
  • Thomas Cech in Hyde Park Civilization on ČT24 26.12.2022 (moderator Daniel Stach)
  • Tom Cech's Short Talk: "Discovering Ribozymes"
  • Chemical and Engineering News
  • The Nobel Prize in Chemistry 1989: Illustrated Presentation
  • HHMI profile
  • HHMI bio
  • HHMI Investigators bio
  • The Official Site of Louisa Gross Horwitz Prize