In physiology, thermoception or thermoreception is the sensation and perception of temperature, or more accurately, temperature differences inferred from heat flux. It deals with a series of events and processes required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal in order to trigger an appropriate response. Thermal stimuli may be noxious (posing a threat to the subject) or innocuous (no threat). The temperature sensitive proteins in thermoreceptors may also be activated by menthol or capsaicin, hence why these molecules evoke cooling and burning sensations, respectively.

A thermoreceptor may absorb heat via conduction, convection or radiation. However, the type of heat transfer is usually irrelevant to the functioning of a thermoceptor. Transient receptor potential channels (TRP channels)