TSR may refer to:
Science and technology
- Terminate-and-stay-resident program, a type of MS-DOS computer program
- Thermochemical sulfate reduction, reducing sulfate to sulfide
- Tip-speed ratio, of a wind turbines
- Temporary speed restriction, UK railway term
- Traffic-sign recognition, by equipment in vehicles
Military
- BAC TSR-2, a prototype British bomber
- TSR I and II, prototypes of the Fairey Swordfish torpedo bomber
- FN Tactical Sport Rifle
- Transvaal Scottish Regiment
Arts, media and culture
- TSR, Inc., game publisher
- Télévision Suisse Romande, a French-language Swiss TV channel
- Full Metal Panic! The Second Raid, an anime
- Team Sonic Racing, a video game
- True Symphonic Rockestra, an opera-oriented project
- "T.S.R. (Toilet Stool Rap)", song from Biz Markie's album I Need a Haircut
- The Shade Room, media company
Organizations
- Telford Steam Railway, UK
- Texas State Railroad, US
- Toronto Street Railway (horse-drawn), 1861-1891
- Former Toronto Suburban Railway
- Timișoara Traian Vuia International Airport, Romania, IATA code
- Trans-Siberian Railway
- TSR Records
- Tactical Studies Rules, defunct game publishing company
Other uses
- Travelling stock route, Australia
- Treno Servizio Regionale, Italian trains
- Total shareholder return
- Traditional Spelling Revised, a relatively conservative English-language spelling reform