The initials TPK may refer to:
Arts and entertainment
- Total party kill, in role-playing games
- The Paper Kingdom, an unreleased album by My Chemical Romance
Businesses and organisations
- Tai Ping Koon Restaurant, Hong Kong
- Te Puni Kōkiri, a New Zealand government department
- Turun Pallokerho, a Finnish football club
Other uses
- TPK algorithm, in computer science
- Traditional Phenological Knowledge, in anthropology