TLE may stand for:

Arts and entertainment

  • The Living End, an Australian band formed in 1994
  • Star Trek: The Lost Era, a novel series in the Star Trek franchise
  • Lost Experience, a game based on the Lost television series

Medicine

  • Temporal lobe epilepsy, the most common form of focal seizure, originating in the temporal lobe of the brain

Science and technology

  • Kimber Custom TLE II, a model of the Kimber Custom handgun
  • Temporal light effects, wanted or unwanted effects caused by light modulations
  • Total lunar eclipse, an astronomical event
  • Transient luminous event, or upper-atmospheric lightning, a weather phenomenon
  • Two-line element set, a format for distributing orbital element data

Other uses

  • Technology and Livelihood Education, part of an educational curriculum in the Philippines
  • The London Economic, a left-wing digital newspaper based in the UK

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