TFM may refer to:
Arts and entertainment
- TFM (radio), North-East England
- Transformice, a 2010 French online game
- The Fame Monster, a 2009 album by Lady Gaga
Science and technology
- TFM (piscicide), a poison for fish
- TeX font metric, a typeface file format
- Thin-film composite membrane
- Total fatty matter, a metric for soap
- Traction force microscopy, in cellular biology
- Trifluoromescaline, a psychedelic drug
Transport
- Grupo Transportación Ferroviaria Mexicana, a Mexican rail operator
- Transportes Ferroviarios de Madrid, a concessionaire for Madrid Metro Line 9