Steven A. Frank (born November 8, 1957) is an American evolutionary biologist and Donald Bren Professor and UCI Distinguished Professor of Biological Sciences at the University of California, Irvine.

Frank uses mathematical and computational models to study evolutionary biology, including social evolution, infectious disease, cancer evolution, and the theory of natural selection. He joined the faculty at the University of California, Irvine in 1988 as an assistant professor, was promoted to associate professor in 1992, and to full professor in 1997. He was named UCI Distinguished Professor in 2015 and Donald Bren Professor in 2016.

Frank has held visiting appointments at several research institutions, including the Wissenschaftskolleg zu Berlin (Institute for Advanced Study) three times (1996–1997, 2006–2007, and 2014–2015), the Institute for Advanced Study in Princeton (2002), the Santa Fe Institute (2009), the University of Chicago as Hogge-Baer Visiting Professor in Cancer Research (2011–2012), and ETH Zürich as Velux Visiting Professor and later Visiting Professor (2013 and 2018–2019).

  • Miller Research Fellowship, University of California, Berkeley, 1987–1989
  • Presidential Young Investigator Award, National Science Foundation, 1990
  • Fellow, American Association for the Advancement of Science, elected 2009
  • Fellow, American Academy of Arts and Sciences, elected 2012

Frank's work on social evolution includes the 1998 book Foundations of Social Evolution. Reviewers discussed its treatment of the Price equation, relatedness, and kin selection theory. Alan Grafen later wrote that Frank's work helped extend optimization methods in social evolution.

The fig wasp Pegoscapus franki was named after Frank in recognition of his early work on fig wasps.

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