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Spike Island may refer to:
Australia
- Spike Island (Tasmania)
England
- Spike Island, Bristol, an area of the English port city of Bristol, adjoining the city centre
- Spike Island, Widnes, a park in Widnes
- Spike Island (Southampton), the area bounded by the River Itchen and River Hamble in Hampshire
- Spike Island, former name for Northumberland Heath, London
- Spike Island railway station, a workman's platform situated off the Great Northern Railway's main line south of Doncaster
Ireland
- Spike Island, County Cork, an island in Cork Harbour, Ireland
Other
- Spike Island (concert), a 1990 concert headlined by the Stone Roses in Widnes, England
- Spike Island (song), a 2025 single by Pulp inspired by the concert
- Spike Island (film), a 2012 British comedy film based on the 1990 concert
- Spike Island Artspace, a centre for contemporary art in Bristol, England