Spencerville may refer to:
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Places
- Spencerville, Ontario, Canada
- Spencerville, New Zealand
United States
- Spencerville, Indiana
- Spencerville, Maryland
- Spencerville Adventist Academy, Maryland
- Spencerville, New Mexico
- Spencerville, Ohio
- Spencerville, Oklahoma
Other uses
- Spencerville (novel), by Nelson DeMille
- Spencerville, the fictional location of children's television program Hallo Spencer