Southworth may refer to:
People
- Southworth (surname)
Places
- Southworth, Ohio, an unincorporated community
- Southworth, Washington – unincorporated community on Puget Sound in Kitsap County, Washington
- Point Southworth – on Kitsap Peninsula on the western side of the northern entrance to Colvos Passage in Puget Sound
- Southworth Creek, a stream in Oregon
Others uses
- Southworth & Hawes – an early photographic firm in Boston.