thumb|Sosthenes
Sosthenes (Greek: Σωσθένης, Sōsthénēs, "safe in strength") was the chief ruler of the synagogue at Corinth, who, according to the Acts of the Apostles, was seized and beaten by the mob in the presence of Gallio (c. 5 BC – c. AD 65), the Roman governor, when Gallio refused to proceed against Paul (c. 5 – c. 64/65 AD) at the instigation of the Jews (). The motives of this assault against Sosthenes are not recorded. Some manuscripts assert the mob was composed of "Greeks" () while others read "Jews".
Some historians, beginning with Eusebius, identify this Sosthenes with a companion of Paul the Apostle referred to as "Sosthenes our brother" (, Sōsthénēs ho adelphós, literally "Sosthenes the brother"), a convert to the Christian faith and co-author of the First Epistle to the Corinthians (). It is not clear whether this identification is tenable. The name was a common one.
He is traditionally listed among the Seventy Disciples of .