Sirius is also the name of the titular character of Olaf Stapledon's 1944 novel "Sirius" which examines what it would be like to be the only intelligent dog in the world. Stars in Orion are used on the original cover to form the body of a dog with his nose sniffing Alpha Canis Majoris.

Throughout the 1990s, several members of the occult group the Order of the Solar Temple committed mass murder-suicide with the goal of leaving their bodies and spiritually "transiting" to Sirius. In total, 74 people died in all of the suicides and murders.

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