thumb|350px|Districts of Sirdaryo Region
Sirdaryo Region () is one of the regions of Uzbekistan, located in the center of the country on the left bank of the Syr Darya. It borders with Kazakhstan, Tajikistan, Tashkent Region, and Jizzakh Region. It covers an area of , and is mostly desert, with the Mirzachoʻl taking up a significant part of the region's area. The population is estimated to be 860,900 (2021).
Established on February 16, 1963.
The capital is the city of Guliston (pop. est. 91,300, 2021).
{| class="wikitable sortable"
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! Key || District name || District name (uzbek) || District capital
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| 1 || Oqoltin District || Oqoltin tumani || Sardoba
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| 2 || Boyovut District || Boyovut tumani || Boyovut
|-
| 3 || Guliston District || Guliston tumani || Dehqonobod
|-
| 4 || Xovos District || Xovos tumani || Xovos
|-
| 5 || Mirzaobod District || Mirzaobod tumani || Navroʻz
|-
| 6 || Sardoba District || Sardoba tumani || Paxtaobod
|-
| 7 || Sayxunobod District || Sayxunobod tumani || Sayxun
|-
| 8 || Sirdaryo District || Sirdaryo tumani || Sirdaryo
|}
There are 5 cities (Guliston, Shirin, Yangiyer, Sirdaryo, Baxt) and 25 urban-type settlements in the Sirdaryo Region.
Climate
The climate is a typically arid continental climate with extreme differences between winter and summer temperatures.
Economy
The economy is based on cotton and cereal crops, with strong reliance on irrigation and on cattle breeding. Minor crops include forage plants, vegetables, melons, gourds, potatoes, maize, a variety of fruit and grapes. Industry consists of construction materials, irrigation equipment and raw-cotton processing.
Syrdarya contains one of Uzbekistan's largest hydroelectric power plants, which generates one third of the country's electricity.