The 1545–1546 was part of a failed attempt by the Uesugi clan to regain Kawagoe Castle from the Later Hōjō clan in the Sengoku period of Japan.
Uesugi Tomosada of the Ogigayatsu branch of the Uesugi clan attacking Kawagoe castle, he was joined by his more powerful relative Uesugi Norimasa from Yamanouchi branch Uesugi clan, who held the post of Kantō Kanrei, the shōgun's deputy in the Kantō region by Ashikaga Haruuji, the Kantō kubō in Koga, and by a host of anti-Hōjō daimyō from the Kantō region.
Background
The eldest legitimate son of Uesugi Tomooki of Ōgigayatsu, following his father's death in 1537, though he was still a child, Uesugi Tomosada led an attack on the Later Hōjō clan in the Tachibana district of Musashi province. He established himself in the temple of Kandai-ji, which he fortified as a castle. However, Hōjō Ujitsuna took Kawagoe castle soon afterwards from Tomosada's uncle, Uesugi Tomonari.
In 1545, Tomosada attempt to regain the Kawagoe castle for the Uesugi clan. Tomosada allied himself with Ashikaga Haruuji and Uesugi Norimasa of Yamauchi against Hōjō Ujiyasu.