Sempill or Semple may refer to:
<!-- is a lowland Scottish clan whose origins center around current day Renfrew and Paisley, Scotland to the west of Glasgow. The first written record of the name occurs in 1280 and mentions Robert de Semple as Steward of the Barony of Renfrew. -->
People
- Francis Sempill (1616?–1682), Scottish writer, son of Robert the younger
- James Sempill (1566–1626), Scottish courtier and diplomat
- Hugh Sempill (1596–1654), Scottish mathematician
- Robert Sempill (c.1530–1595), Scottish balladeer
- Robert Sempill the younger (1595?–1663?), Scottish writer, son of Robert
- William Forbes-Sempill, 19th Lord Sempill (1893–1965), Scottish pioneering aviator and Japanese spy
Other uses
- Clan Sempill, a Lowland Scottish clan
- Lord Sempill, a title in the Peerage of Scotland
- Sempill Mission, a 1921 military mission to Japan