The Seine is a river in France.
Seine River may also refer to:
;Rivers
- Seine River (Ontario)
- Seine River (Manitoba)
- St. Marys River (Florida–Georgia), named the Seine River in 1652 by French explorer Jean Ribault, later renamed by the Spanish.
;Other uses
- Seine River (electoral district), a provincial electoral district in Manitoba
- Seine River First Nation, an Ojibwe nation in Ontario