Santo Antão, Portuguese for "Saint Anthony", may refer to the following places.
Brazil
- Vitória de Santo Antão, Pernambuco
Cape Verde
- Santo Antão, Cape Verde, the northwesternmost island in Cape Verde archipelago
Portugal
- Santo Antão (Évora), a civil parish in the municipality of Évora
- Santo Antão do Tojal, a civil parish in the municipality of Loures
- Santo Antão (Calheta), a civil parish in the municipality of Calheta, São Jorge, Azores